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(1) In a study of the susceptibility of 115 strains of staphylococci to penicillin 16 or 13.9% were found to be resistant. (2) All strains resistant to penicillin produced penicillinase; none of the susceptible strains had this property. (3) Many of the penicillinase-producing staphylococci produce coagulase indicating the importance of the former in infection. (4) Staphylococci naturally resistant to penicillin appear to be resistant as a result of their ability to produce penicillinase.
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Bondi et al. (1945) studied this question.
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