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September 15, 2005Journal of Biological ChemistryOpen Access

Nucleocytoplasmic Shuttling of the Splicing Factor SIPP1

Miriam Llorian Monique Beullens Bart Lesage Emilia Nicolaescu Lijs Beke Willy Landuyt José-Miguel Ortiz Mathieu Bollen

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Key Points

To investigate the role of SIPP1 in pre-mRNA splicing and its nucleocytoplasmic shuttling mechanism.
Identified nucleocytoplasmic shuttling of SIPP1 under radiation stress
Examined SIPP1's interactions with PQBP1 and PP1 in the nucleus
Analyzed splicing activation correlated with SIPP1 concentration in cells.
SIPP1 predominantly localized in the nucleus; translocated to the cytoplasm post-UV/X-radiation
SIPP1 and PQBP1 formed inclusion bodies akin to those in polyglutamine disorders
Increased SIPP1 concentration in the nucleus enhanced pre-mRNA splicing activity.

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Implication

Uncovers roles of SIPP1 in pre-mRNA splicing, indicating potential links to neurodegenerative diseases.

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Cite This Study

Llorian et al. (2005) studied this question.

synapsesocial.com/papers/6a21c5d6033871db2707c2fb https://doi.org/10.1074/jbc.m509185200

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