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Background: Psoriasis is a complex autoimmune multifactorial disease induced by interaction of environmental and genetic factors. This research aimed to clarify the association of NLRP3 (rs10754558) and PTPN22 (1858C/T) (rs2476601) polymorphisms with susceptibility to psoriasis. Methods: This case–control study involved 150 patients diagnosed with psoriasis and 100 age- and gender-matched apparently healthy individuals. NLRP3 (rs10754558) polymorphism was done by real time PCR and PTPN22 1858C/T (rs2476601) genotype was identified by tetra-primer amplification refractory mutation system-polymerase chain reaction (PCR) method. Results: The genotypes distribution of NLRP3 (rs10754558) were significantly associated with psoriasis ( p < 0.0001). Whereas for PTPN22 (1858C/T) (rs2476601), no significance was found ( p =0.09). NLRP3 (rs10754558) GC genotype revealed a significant association with psoriasis ( p < 0.0001), mainly among male ( p =0.004) patients with mild psoriasis ( p =0.001) and affected extremities ( p =0.0001). Conclusion: We can conclude that the NLRP3 (rs10754558) GC genotype may play a role in psoriasis susceptibility among male Egyptian populations with affected extremities. Future studies must evaluate its role in the prevention or the treatment of psoriasis.
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ALrefai et al. (2021) studied this question.
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