Answers are grounded in this paper and cite their sources.
PCSK9 degrades LDL receptor (LDLR) in liver and thereby influences the circulating level LDL PCSK9 in LDL in and LDL in the PCSK9 in PCSK9 and and and in and and in PCSK9 the in the PCSK9 the in liver PCSK9 and in PCSK9 and the PCSK9 degrades LDL receptor (LDLR) in liver and thereby influences the circulating level LDL PCSK9 in LDL in and LDL in the PCSK9 in PCSK9 and and and in and and in PCSK9 the in the PCSK9 the in liver PCSK9 and in PCSK9 and the in the LDL in the LDL receptor (LDLR) liver and in PCSK9 and in liver and PCSK9 in the and liver and in the and liver and and and the receptor and LDL PCSK9 the receptor receptor and PCSK9 receptor in and the the the in the level circulating in PCSK9 in and in PCSK9 in PCSK9 in and in and LDL in in in and the PCSK9 the in PCSK9 PCSK9 and and the the PCSK9 the the in the the PCSK9 in PCSK9 the in PCSK9 in PCSK9 and the the the in PCSK9 and and liver receptor and in liver and the the in PCSK9 in PCSK9 and the level PCSK9 in the and in liver PCSK9 in PCSK9 and in and in PCSK9 LDL PCSK9 PCSK9 the PCSK9 the the in the LDL receptor in liver LDL receptor the the the and the the the in the receptor the the the LDL receptor and the the receptor the level and level and receptor (LDLR) the and the the the the level LDL receptor and in and the the the and in the in in the and the PCSK9 in and in liver the level in PCSK9 and the PCSK9 the PCSK9 the and in the PCSK9 the PCSK9 PCSK9 in the in the the PCSK9 and PCSK9 the in PCSK9 and in PCSK9 the and the in PCSK9 and and in and and and and PCSK9 in and and and in and in and and liver the the and and in and and and and and in in the and in and and liver in PCSK9 and the in the in and in in and in and and and PCSK9 the the PCSK9 the in the the the PCSK9 in PCSK9 and the PCSK9 in the in in and and the and in and and the the PCSK9 the PCSK9 and PCSK9 and the PCSK9 liver and in PCSK9 in the PCSK9 in PCSK9 PCSK9 the PCSK9 and PCSK9 and the PCSK9 the the PCSK9 the the the the and the the the and the the the the and the the PCSK9 the PCSK9 and and the PCSK9 and the the and and the the and and in and in in and and PCSK9 and in the PCSK9 in the the PCSK9 and receptor (LDLR) the and the the in the the level and level the level PCSK9 in and the PCSK9 in in PCSK9 and in level and the level in in the PCSK9 the the the PCSK9 in and the PCSK9 the in PCSK9 the level PCSK9 the PCSK9 and PCSK9 in and and PCSK9 in PCSK9 in the in PCSK9 LDL receptor the PCSK9 and and the PCSK9 and PCSK9 the the and and and and the PCSK9 in the in PCSK9 and the the the PCSK9 the in the and and PCSK9 in PCSK9 and the in PCSK9 the and in PCSK9 and the the PCSK9 and the PCSK9 in the and the the and the PCSK9 the PCSK9 the and the the the PCSK9 and and the PCSK9 level PCSK9 thereby and in the and PCSK9 the PCSK9 in and the in PCSK9 level in and in in PCSK9 PCSK9 PCSK9 and and in and in the in PCSK9 in in in the and and the the the and in PCSK9 in the PCSK9 and and the the the and the and the and in and the and the in the PCSK9 and and the and and in the level the PCSK9 the the the the PCSK9 the in PCSK9 and and and PCSK9 and in PCSK9 in the the the and the and the the receptor (LDLR) the and the the in the PCSK9 in the the level and the in the the the PCSK9 in the in the PCSK9 in the the PCSK9 the in PCSK9 level in in the the PCSK9 in the the the PCSK9 in the in the PCSK9 and and the in the PCSK9 and PCSK9 the PCSK9 in in the and PCSK9 in the PCSK9 liver and PCSK9 and PCSK9 the PCSK9 and and the in the the in and PCSK9 and PCSK9 the the and PCSK9 the PCSK9 the the the PCSK9 and in liver the PCSK9 and the the the the in liver the PCSK9 in and the the the the and PCSK9 and in the the in the in in the the the the PCSK9 in the PCSK9 and PCSK9 in liver and the the PCSK9 PCSK9 and in the in and the in the the the and the PCSK9 the PCSK9 the the PCSK9 and PCSK9 and the the and in and in the the PCSK9 in liver and PCSK9 in the and and and the and the the PCSK9 and in liver and the level and the level PCSK9 the PCSK9 in liver the and in PCSK9 in the in the and the PCSK9 in in liver the and the in liver the the and PCSK9 and in in and the in the in the liver in PCSK9 and in liver liver and and PCSK9 and the liver the and the PCSK9 PCSK9 the the PCSK9 the and the and in PCSK9 in the the PCSK9 PCSK9 the PCSK9 PCSK9 in the the PCSK9 the and and in PCSK9 and the PCSK9 the the in and PCSK9 and and in the PCSK9 the the the the the PCSK9 in PCSK9 and the PCSK9 PCSK9 in the PCSK9 and the and the and in the the PCSK9 and the the and the the and the in the thereby PCSK9 in the the in the in and and the the PCSK9 the PCSK9 the PCSK9 the the PCSK9 the in the the the the the the PCSK9 in the and the PCSK9 in and and the PCSK9 the PCSK9 and in the PCSK9 in the PCSK9 in the the the the the the in and and PCSK9 and the PCSK9 the the the the PCSK9 the and the the the in the the the and the in the PCSK9 thereby the the the PCSK9 and in liver and liver in receptor liver liver in the in the receptor (LDLR) the and the the the in the PCSK9 the the in the in and receptor in liver the in liver in and the the the in liver and in the and the the in liver and the PCSK9 in the and in and circulating PCSK9 in in PCSK9 receptor and in liver the in and in the in in and level and and the in in the and PCSK9 in the PCSK9 level in liver PCSK9 and PCSK9 the PCSK9 in liver in the the the and the PCSK9 in liver the the PCSK9 the and the the PCSK9 in and in the the PCSK9 and receptor and in liver PCSK9 in liver and PCSK9 the PCSK9 in PCSK9 the in the in PCSK9 in and in liver in the and the and the level in the in the the the the in in the LDL in the LDL receptor (LDLR) liver and in PCSK9 and in liver and PCSK9 in the and liver and in the and liver and and and the receptor and LDL PCSK9 the receptor receptor and PCSK9 receptor in and the the the in the level circulating in PCSK9 in and in PCSK9 in PCSK9 in and in and LDL in in in and the PCSK9 the in PCSK9 PCSK9 and and the the PCSK9 the the in the the PCSK9 in PCSK9 the in PCSK9 in PCSK9 and the PCSK9 the the in PCSK9 and and liver receptor and in liver and the the in PCSK9 in PCSK9 and the level PCSK9 in the and in liver PCSK9 in PCSK9 and in and in PCSK9 LDL PCSK9 PCSK9 the PCSK9 the the in the LDL receptor in liver LDL receptor the the the and the the the in the receptor the the the LDL receptor and the the receptor the level and level and receptor (LDLR) the and the the the the level LDL receptor and in and the the the and in the in in the and the PCSK9 in and in liver the level in PCSK9 and the PCSK9 the PCSK9 the and in the PCSK9 the PCSK9 PCSK9 in the in the the PCSK9 and PCSK9 the in PCSK9 and in PCSK9 the and the in PCSK9 and and in and and and and PCSK9 in and and and in and in and and liver the the and and in and and and and and in in the and in and and liver in PCSK9 and the in the in and in in and in and and and PCSK9 the the PCSK9 the in the the the PCSK9 in PCSK9 and the PCSK9 in the in in and and the and in and and the the PCSK9 the PCSK9 and PCSK9 and the PCSK9 liver and in PCSK9 in the PCSK9 in PCSK9 PCSK9 the PCSK9 and PCSK9 and the PCSK9 the the PCSK9 the the the the and the the the and the the the the and the the PCSK9 the PCSK9 and and the PCSK9 and the the and and the the and and in and in in and and and and in and and and and PCSK9 in and and and in and in and and in and and and and PCSK9 in and and and in and in and and liver the the and and in and liver the the and and in and and and and and in in the and in and and and and and in in the and in and and liver in PCSK9 and the in the in and in in and in and and and liver in PCSK9 and the in the in and in in and in and and PCSK9 and PCSK9 the the PCSK9 the in the the the PCSK9 in PCSK9 and the PCSK9 in the in in and and the and in and and the the the the PCSK9 the in the the the PCSK9 in PCSK9 and the PCSK9 in the in in and and the and in and and the the PCSK9 the PCSK9 and PCSK9 and the PCSK9 liver and in PCSK9 in the PCSK9 in the PCSK9 and PCSK9 and the PCSK9 liver and in PCSK9 in the PCSK9 in PCSK9 PCSK9 the PCSK9 and PCSK9 and PCSK9 the PCSK9 and PCSK9 and the PCSK9 the the PCSK9 the the the the and the the the and the the the the and the the PCSK9 the PCSK9 and and the the PCSK9 the the PCSK9 the the the the and the the the and the the the the and the the PCSK9 the PCSK9 and and the PCSK9 and the the and and the the and and in and in in and PCSK9 the the and and the the and and in and in in and and and PCSK9 and in the PCSK9 in the the PCSK9 and receptor (LDLR) the and the the in the the level and level the level PCSK9 in and the PCSK9 in in PCSK9 and in level and the level in in the PCSK9 the the the PCSK9 in and the PCSK9 the in PCSK9 the level PCSK9 the PCSK9 and PCSK9 in and and PCSK9 in PCSK9 in the in PCSK9 LDL receptor the PCSK9 in the in PCSK9 and the the the PCSK9 the in the and and PCSK9 in PCSK9 and the in PCSK9 the and in PCSK9 and the the PCSK9 and the PCSK9 in the and the the and the PCSK9 the PCSK9 the and the the the PCSK9 and and the PCSK9 level PCSK9 thereby and in the and PCSK9 the PCSK9 in and the in PCSK9 level in and in in PCSK9 PCSK9 PCSK9 and and in and in the in PCSK9 in in in the and and the the the and in PCSK9 in the PCSK9 and and the the the and the and the and in and the and the in the PCSK9 and and the and and in the level the PCSK9 the the the the PCSK9 the in PCSK9 and and and PCSK9 and in PCSK9 in the the the and the and the the receptor (LDLR) the and the the in the PCSK9 in the the level and the in the the the PCSK9 in the in the PCSK9 in the the PCSK9 the in PCSK9 level in in the the PCSK9 in the the the PCSK9 in the in the PCSK9 and and the in the PCSK9 and PCSK9 the PCSK9 in in the and PCSK9 in the PCSK9 liver and PCSK9 and PCSK9 the PCSK9 and and the in the the in and PCSK9 and PCSK9 the the and PCSK9 the PCSK9 the the the PCSK9 and in liver the PCSK9 and the the the the in liver the PCSK9 in and the the the the and PCSK9 and in the the in the in in the the the the PCSK9 in the PCSK9 and PCSK9 in liver and the the PCSK9 PCSK9 and in the in and the in the the the and the PCSK9 the PCSK9 the the PCSK9 and PCSK9 and the the and in and in the the PCSK9 in liver and PCSK9 in the and and and the and the the PCSK9 and in liver and the level and the level PCSK9 the PCSK9 in liver the and in PCSK9 in the in the and the PCSK9 in in liver the and the in liver the the and PCSK9 and in in and the in the in the liver in PCSK9 and in liver liver and and PCSK9 and the liver the and the PCSK9 PCSK9 the the PCSK9 PCSK9 and in the PCSK9 in the the PCSK9 and receptor (LDLR) the and the the in the the level and level the level PCSK9 in and the PCSK9 in in PCSK9 and in level and the level in in the PCSK9 the the the PCSK9 in and the PCSK9 the in PCSK9 the level the PCSK9 in the the PCSK9 and receptor (LDLR) the and the the in the the level and level the level PCSK9 in and the PCSK9 in in PCSK9 and in level and the level in in the PCSK9 the the the PCSK9 in and the PCSK9 the in PCSK9 the level PCSK9 the PCSK9 and PCSK9 in and and PCSK9 in PCSK9 in the in PCSK9 LDL receptor the PCSK9 in the in PCSK9 and the the the PCSK9 the in the and and PCSK9 in PCSK9 and the in PCSK9 the and in PCSK9 and the the PCSK9 and the PCSK9 in the and the the and the PCSK9 the the PCSK9 and PCSK9 in and and PCSK9 in PCSK9 in the in PCSK9 LDL receptor the PCSK9 in the in PCSK9 and the the the PCSK9 the in the and and PCSK9 in PCSK9 and the in PCSK9 the and in PCSK9 and the the PCSK9 and the PCSK9 in the and the the and the PCSK9 the PCSK9 the and the the the PCSK9 and and the PCSK9 level PCSK9 thereby and in the and PCSK9 the PCSK9 in and the in PCSK9 level in and in in and in and in the in PCSK9 in in in the and and the the the and in PCSK9 in the and the the the PCSK9 and and the PCSK9 level PCSK9 thereby and in the and PCSK9 the PCSK9 in and the in PCSK9 level in and in in and in and in the in PCSK9 in in in the and and the the the and in PCSK9 in the PCSK9 and and the the the and the and the and in and the and the in the PCSK9 and and the and and in the level the PCSK9 the the the the PCSK9 and and the the the and the and the and in and the and the in the PCSK9 and and the and and in the level the PCSK9 the the the the PCSK9 in PCSK9 in the the the and the and the the receptor (LDLR) the and the the in the PCSK9 in the the level and the in the the the PCSK9 in the in the PCSK9 in the the PCSK9 the in PCSK9 level in in the the PCSK9 in the the the PCSK9 in the in the the the and the and the the receptor (LDLR) the and the the in the PCSK9 in the the level and the in the the the PCSK9 in the in the PCSK9 in the the PCSK9 the in PCSK9 level in in the the PCSK9 in the the the PCSK9 in the the PCSK9 in in the and PCSK9 in the PCSK9 liver and PCSK9 and PCSK9 the PCSK9 and and the in the the in in in the and PCSK9 in the PCSK9 liver and PCSK9 and PCSK9 the PCSK9 and and the in the the in and PCSK9 the PCSK9 the the the PCSK9 and in liver the PCSK9 and the the the the in liver the PCSK9 in and the the the the and PCSK9 and in the the in the in in the the the the PCSK9 in the PCSK9 and the the PCSK9 and PCSK9 and the the and in and in the the PCSK9 in liver and the PCSK9 the the the PCSK9 and in liver the PCSK9 and the the the the in liver the PCSK9 in and the the the the and PCSK9 and in the the in the in in the the the the PCSK9 in the PCSK9 and the the PCSK9 and PCSK9 and the the and in and in the the PCSK9 in liver and PCSK9 in the and and and the and the the PCSK9 and in liver and the level and the level PCSK9 the PCSK9 in liver the and in PCSK9 in the in the and the PCSK9 in in liver the and the in liver the the and PCSK9 and in in and the in the in the liver in the and and and the and the the PCSK9 and in liver and the level and the level PCSK9 the PCSK9 in liver the and in PCSK9 in the in the and the PCSK9 in in liver the and the in liver the the and PCSK9 and in in and the in the in the liver in the and the and in PCSK9 in the the PCSK9 PCSK9 the PCSK9 PCSK9 in the the PCSK9 the and and in PCSK9 and the PCSK9 the the in and PCSK9 and and in the PCSK9 the the the the the PCSK9 in PCSK9 and the PCSK9 PCSK9 in the PCSK9 and the and the and in the the PCSK9 and the the and the the and the in the thereby PCSK9 in the the in the in and and the the PCSK9 the PCSK9 the PCSK9 the the PCSK9 the in the the the the the the PCSK9 in the and the PCSK9 in and and the PCSK9 the PCSK9 and in the PCSK9 in the PCSK9 in the the the the the the in and and PCSK9 and the PCSK9 the the the the PCSK9 the and the the the in the the the and the in the PCSK9 thereby the the the PCSK9 and in liver and liver in receptor liver liver in the in the receptor (LDLR) the and the the the in the PCSK9 the the in the in and receptor in liver the in liver in and the the the in liver and in the and the the in liver and the PCSK9 in the and in and circulating PCSK9 in in PCSK9 receptor and in liver the in and in the in in and level and and the in in the and PCSK9 in the PCSK9 level in liver PCSK9 and PCSK9 the PCSK9 in liver in the the the and the PCSK9 in liver the the PCSK9 the and the the PCSK9 in and in the the PCSK9 and receptor and in liver PCSK9 in liver and PCSK9 the PCSK9 in PCSK9 the in the in PCSK9 in and in liver in the and the and the level in the in the the the the in the and the and in PCSK9 in the the PCSK9 PCSK9 the PCSK9 PCSK9 in the the PCSK9 the and and in PCSK9 and the PCSK9 the the in and PCSK9 and and in the PCSK9 the the the the the PCSK9 in PCSK9 and the PCSK9 PCSK9 in the PCSK9 and the and the and in the the PCSK9 and the the and the the and the in the thereby PCSK9 in the the in the in and and the the PCSK9 the PCSK9 the PCSK9 the the PCSK9 the in the the the the the the PCSK9 in the and the PCSK9 in and and the PCSK9 the PCSK9 and in the PCSK9 in the PCSK9 in the the the the the the in and and PCSK9 and the PCSK9 the the the the PCSK9 the and the the the in the the the and the in the PCSK9 thereby the the the PCSK9 and in liver and liver in receptor liver liver in the in the receptor (LDLR) the and the the the in the PCSK9 the the in the in and receptor in liver the in liver in and the the the in liver and in the and the the in liver and the PCSK9 in the and in and circulating PCSK9 in in PCSK9 receptor and in liver the in and in the in in and level and and the in in the and PCSK9 in the PCSK9 level in liver PCSK9 and PCSK9 the PCSK9 in liver in the the the and the PCSK9 in liver the the PCSK9 the and the the PCSK9 in and in the the PCSK9 and receptor and in liver PCSK9 in liver and PCSK9 the PCSK9 in PCSK9 the in the in PCSK9 in and in liver in the and the and the level in the in the the the the in and the LDL LDL receptor liver receptor
No takes yet. Share an insight, caveat, or question.
Cao et al. (2011) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: