Key result
Magnesium sulfate combined with labetalol increased the treatment effective rate to 97.6% compared to 90.4% with magnesium sulfate alone in patients with pregnancy-induced hypertension (P<0.05).
Why the study?
To explore the hemodynamic changes of magnesium sulfate combined with labetalol in the treatment of pregnancy-induced hypertension under Doppler uterine ultrasound based on the empirical wavelet transform algorithm.
Does labetalol added to magnesium sulfate improve hemodynamics, blood pressure, and birth outcomes in patients with pregnancy-induced hypertension compared to magnesium sulfate alone?
RCT (n=500)
randomly divided
No
Does labetalol added to magnesium sulfate improve hemodynamics, blood pressure, and birth outcomes in patients with pregnancy-induced hypertension compared to magnesium sulfate alone?
The addition of labetalol to magnesium sulfate in pregnancy-induced hypertension significantly improves blood pressure control, uterine artery hemodynamics, and birth outcomes.
Answers are grounded in this paper and cite their sources.
Supports adding labetalol to magnesium sulfate in pregnancy-induced hypertension; extends RCT evidence for combined regimens.
The aim of this study was to explore the hemodynamic changes of magnesium sulfate combined with labetalol in the treatment of pregnancy-induced hypertension (PIH) under Doppler uterine ultrasound based on the empirical wavelet transform (EWT) algorithm. 500 patients with PIH in the hospital were selected and randomly divided into the control group (n = 250) and the observation group (n = 250). The control group was treated with conventional magnesium sulfate; the observation group was given labetalol based on magnesium sulfate drip in the control group. The uterine artery blood flow simulation model was established based on the EWT algorithm and compared with a short-time Fourier transform (STFT). The normalized root mean square error (NRMSE) of the STFT method was 0.19, and the NRMSE extracted by the EWT method was 0.13. After treatment, the blood pressure index, 24-hour urinary protein, and incidence of adverse birth outcomes in the observation group were lower than those in the control group; the effective rate of the control group (90.4%) was lower than that of the observation group (97.6%); the hemodynamic indexes of the uterine artery in the observation group were lower than those in the control group, and the differences were statistically significant ( <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" id="M1"> <a:mi>P</a:mi> <a:mo><</a:mo> <a:mn>0.05</a:mn> </a:math> ). The estimation accuracy of the EWT method was higher than that of the traditional STFT method; the combined treatment of magnesium sulfate and labetalol in patients with PIH had a remarkable effect, which could control the blood pressure index and reduce the 24-hour urinary protein; the uterine artery Doppler ultrasound examination could change hemodynamics and improve the adverse outcomes of mothers and infants.
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Liu et al. (2022) conducted an RCT in pregnancy-induced hypertension (PIH) (n=500). Magnesium sulfate combined with labetalol vs. Conventional magnesium sulfate was evaluated on Effective rate (p=<0.05). Magnesium sulfate combined with labetalol increased the treatment effective rate to 97.6% compared to 90.4% with magnesium sulfate alone in patients with pregnancy-induced hypertension (P<0.05).
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