Key result
A novel formula and decision tree predicted colectomy following intravenous ciclosporin treatment for severe ulcerative colitis with 88.5% and 90.4% accuracy, respectively.
Why the study?
What factors predict response to intravenous ciclosporin in patients with severe ulcerative colitis?
Population
52 patients diagnosed with refractory severe ulcerative colitis, 36.5% men, average age 40.2 ± 15.6 years…
Design
Cohort
Authors
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May aid day-3 colectomy risk stratification in severe UC on IV ciclosporin; hypothesis-generating pending prospective validation.
Observational (n=52)
No
What factors predict response to intravenous ciclosporin in patients with severe ulcerative colitis?
A novel prediction formula and decision tree using clinical parameters on day 3 can accurately predict the need for colectomy in severe ulcerative colitis patients treated with intravenous ciclosporin.
Saito et al. (2012) conducted an observational in severe ulcerative colitis (n=52). Intravenous ciclosporin was evaluated on Response to intravenous ciclosporin treatment (avoidance of colectomy). A novel formula and decision tree predicted colectomy following intravenous ciclosporin treatment for severe ulcerative colitis with 88.5% and 90.4% accuracy, respectively.
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