Key result
COVID-19 vaccines, including mRNA and adenovirus-vector types, are associated with overall rare neurologic adverse events that can carry significant morbidity and mortality.
Why the study?
Potential safety risks of novel COVID-19 vaccines must be monitored, identified, and quantified, particularly rare neurologic adverse events associated with significant morbidity and mortality.
This review summarizes current data on rare but potentially severe neurologic adverse events associated with COVID-19 vaccines.
Answers are grounded in this paper and cite their sources.
Warrants ongoing post-vaccination neurologic surveillance; leaves open precise incidence and causality across platforms.
The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has triggered a global effort to rapidly develop and deploy effective and safe coronavirus disease 2019 (COVID-19) vaccinations. Vaccination has been one of the most effective medical interventions in human history, although potential safety risks of novel vaccines must be monitored, identified, and quantified. Adverse events must be carefully assessed to define whether they are causally associated with vaccination or coincidence. Neurologic adverse events following immunizations are overall rare but with significant morbidity and mortality when they occur. Here, we review neurologic conditions seen in the context of prior vaccinations and the current data to date on select COVID-19 vaccines including mRNA vaccines and the adenovirus-vector COVID-19 vaccines, ChAdOx1 nCOV-19 (AstraZeneca) and Ad26.COV2.S Johnson & Johnson (Janssen/J&J).
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Thakur et al. (2021) conducted a review in Neurologic adverse events following COVID-19 vaccination. COVID-19 vaccines (mRNA and adenovirus-vector) was evaluated on Neurologic adverse events. COVID-19 vaccines, including mRNA and adenovirus-vector types, are associated with overall rare neurologic adverse events that can carry significant morbidity and mortality.
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