Key result
Systolic blood pressure was the best predictor of the extent and severity of extracranial atherosclerotic lesions, whereas none of the evaluated variables predicted intracranial atherosclerosis.
Why the study?
Do blood pressure components predict the extent and severity of intra- and extracranial atherosclerotic lesions in patients with reversible cerebral ischemia?
Observational (n=462)
Yes
Do blood pressure components predict the extent and severity of intra- and extracranial atherosclerotic lesions in patients with reversible cerebral ischemia?
Systolic hypertension is a strong predictor of the severity and extent of extracranial atherosclerotic lesions in patients with reversible cerebral ischemia.
SBP may aid extracranial lesion risk assessment in reversible cerebral ischemia; leaves open intracranial predictors and requires prospective validation.
Utilizing the initial BP assessment in the 462 patients who entered the Italian Multicenter Study of reversible cerebral ischemia, an analysis of the effect of each BP component in respect of presence, extent and severity of atherosclerotic lesions, as displayed by angiography, was carried out separately for lesions located at either intra- or extracranial level. In a multivariate statistical model, among the following variables: sex, age, systolic BP, diastolic BP, cholesterol and smoking, systolic BP was found the best predictor of extent and severity of atherosclerotic lesions at extracranial level. None of the same variables was predictive of the severity of intracranial atherosclerosis. The results of this clinical study may confirm the indication, coming from physiopathologic observations, of a predominant role of systolic hypertension in the process of maintenance and acceleration of atherosclerosis in the large pre-cerebral arteries.
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Inzitari et al. (1986) conducted an observational in Reversible cerebral ischemia (n=462). Systolic blood pressure was evaluated on Presence, extent and severity of atherosclerotic lesions at intra- or extracranial level. Systolic blood pressure was the best predictor of the extent and severity of extracranial atherosclerotic lesions, whereas none of the evaluated variables predicted intracranial atherosclerosis.
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