Key result
Chronic fetal hypoxia and inflammation impact cardiac myogenesis and increase the lifetime risk of heart disease, though their specific effects on cardiac pacemaker cells require further research.
Why the study?
The effects that chronic hypoxic or inflammatory environments exert on cardiac pacemaker cells during complicated pregnancy are poorly understood.
This review highlights the impact of adverse perinatal conditions like chronic hypoxia and inflammation on cardiac pacemaker cell development and future cardiovascular risk.
May inform arrhythmia risk from perinatal insults; leaves open pacemaker cell effects, requiring prospective studies.
Chronic fetal hypoxia and infection are examples of adverse conditions during complicated pregnancy, which impact cardiac myogenesis and increase the lifetime risk of heart disease. However, the effects that chronic hypoxic or inflammatory environments exert on cardiac pacemaker cells are poorly understood. Here, we review the current evidence and novel avenues of bench-to-bed research in this field of perinatal cardiogenesis as well as its translational significance for early detection of future risk for cardiovascular disease.
No takes yet. Share an insight, caveat, or question.
Frasch et al. (2020) conducted a review in Chronic fetal hypoxia and inflammation. Chronic fetal hypoxia and inflammation was evaluated. Chronic fetal hypoxia and inflammation impact cardiac myogenesis and increase the lifetime risk of heart disease, though their specific effects on cardiac pacemaker cells require further research.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: