Key result
An orthostatic diastolic blood pressure drop of ≥8 mmHg 1 minute after standing up was associated with an increased risk of subsequent myocardial infarction (HR 2.00; 95% CI 1.11-3.59).
Why the study?
Does orthostatic hypotension increase the risk of myocardial infarction in home-dwelling elderly persons?
Population
792 home-dwelling persons aged >=70 years living in five municipalities around the city of Oulu
Comparison
Orthostatic hypotension vs Absence of significant orthostatic diastolic BP…
Design
Cohort
Follow-up
mean 3.58 (SD 1.09) years
Authors
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May flag elevated MI risk in elderly for closer monitoring; leaves open prospective validation before clinical adoption.
Cohort (n=792)
Yes
Does orthostatic hypotension increase the risk of myocardial infarction in home-dwelling elderly persons?
Hazard Ratio: 2 (95% CI 1.11–3.59)
Orthostatic diastolic blood pressure drop of >=8 mmHg one minute after standing is a strong predictor of subsequent myocardial infarction in elderly patients.
Luukinen et al. (2004) conducted a cohort in Orthostatic hypotension (n=792). Orthostatic diastolic blood pressure drop ≥8 mmHg 1 min after standing up vs. No such drop in diastolic blood pressure was evaluated on Occurrence of myocardial infarction (HR 2.00, 95% CI 1.11-3.59). An orthostatic diastolic blood pressure drop of ≥8 mmHg 1 minute after standing up was associated with an increased risk of subsequent myocardial infarction (HR 2.00; 95% CI 1.11-3.59).
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