Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity

Nava-Lauson et al. report that linoleic acid potentiates antitumor function of CD8+ T cells by operating a profound metabolic reprogramming that protects from exhaustion and pushes toward a memory phenotype with superior cytotoxic functions. LA-redirected CD8+ T cells are empowered with an improved metabolic and functional fitness within the TME, thereby improving efficacy of ACT-based therapy.