What does this research mean for the field?

Linoleic acid enhances the antitumor function of CD8+ T cells through metabolic reprogramming that prevents exhaustion, promotes a memory phenotype, and improves the efficacy of adoptive cell transfer therapy. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 9, 2023Cell Metabolism276 citationsOpen Access

Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity

CLCarina B. Nava LausonEuropean Institute of Oncology STSilvia TibertiThe University of Texas MD Anderson Cancer Center PCPaola Antonia CorsettoUniversity of Milan

Key Points

Key points are not available for this paper at this time.

Abstract

Nava-Lauson et al. report that linoleic acid potentiates antitumor function of CD8+ T cells by operating a profound metabolic reprogramming that protects from exhaustion and pushes toward a memory phenotype with superior cytotoxic functions. LA-redirected CD8+ T cells are empowered with an improved metabolic and functional fitness within the TME, thereby improving efficacy of ACT-based therapy.

Ask AI

Helpful

Bookmark

View Full Paper