Extractive alkylation enables the rapid and stable benzylation of aspirin with a 95% yield, facilitating its mass spectrometric determination in plasma.
Describes an extractive alkylation method for the mass spectrometric determination of aspirin in plasma with a 95% yield.
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Abstract Extractive alkylation conditions are described which result in the efficient benzylation of ASA and SA. Benzylation is rapid with formation of the ester of ASA which is stable to hydrolysis resulting in a yield of 95%. This reaction was used in the development of a mass spectrometric determination of ASA in plasma using the perdeuterio benzyl ester of ASA as the calibration standard.
Rosenfeld et al. (Tue,) reported a other. Extractive alkylation enables the rapid and stable benzylation of aspirin with a 95% yield, facilitating its mass spectrometric determination in plasma.
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