Key result
Preoperative chemical thromboprophylaxis showed no significant difference compared to postoperative administration for early postoperative DVT (1.6% vs 2.6%; P=0.72).
Why the study?
Does preoperative chemical thromboprophylaxis with subcutaneous heparin reduce postoperative VTE compared to postoperative administration in patients undergoing major colorectal surgery?
RCT (n=376)
Does preoperative chemical thromboprophylaxis with subcutaneous heparin reduce postoperative VTE compared to postoperative administration in patients undergoing major colorectal surgery?
Absolute Event Rate: 1.6% vs 2.6%
p-value: p=0.72
Preoperative and postoperative chemical thromboprophylaxis with subcutaneous heparin provide similar protection against VTE without significant differences in bleeding complications in major colorectal surgery.
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Supports either preoperative or postoperative heparin initiation; confirms equivalence for VTE prevention in colorectal surgery.
Zaghiyan et al. (2016) conducted an RCT in Major colorectal surgery (n=376). Preoperative chemical thromboprophylaxis vs. Postoperative chemical thromboprophylaxis was evaluated on Early postoperative DVT (48-hrs) (p=0.72). Preoperative chemical thromboprophylaxis showed no significant difference compared to postoperative administration for early postoperative DVT (1.6% vs 2.6%; P=0.72).
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