Key result
In a young Chinese general population, higher fasting glucose (OR 1.377), systolic blood pressure, and female sex were independent predictors of incident left ventricular hypertrophy over a 4-year follow-up.
Why the study?
ECG-LVH is a common manifestation of preclinical cardiovascular disease, but its prevalence and risk factors in young Chinese individuals needed investigation.
Cohort (n=1,515)
In a young Chinese general population, female sex, systolic blood pressure, and fasting glucose were identified as independent predictors of incident electrocardiographic left ventricular hypertrophy over a 4-year period.
May warrant closer ECG monitoring in at-risk young adults; hypothesis-generating and should not yet change practice.
BACKGROUND: Electrocardiographic left ventricular hypertrophy (ECG-LVH) is a common manifestation of preclinical cardiovascular disease. The present study aimed to investigate risk factors for ECG-LVH and its prevalence in a cohort of young Chinese individuals. METHODS: (1) A total of 1515 participants aged 36-45 years old from our previously established cohort who were followed up in 2017 were included. Cross-sectional analysis was used to examine risk factors for ECG-LVH and its prevalence. (2) A total of 235 participants were recruited from the same cohort in 2013 and were followed up in 2017. Longitudinal analysis was used to determine the predictors of LVH occurrence over the 4-year period. We used multivariable logistic regression models to calculate OR and 95% CIs and to analyze risk factors for ECG-LVH. RESULTS: In the cross-sectional analysis, the prevalence of LVH diagnosed by the Cornell voltage-duration product in the overall population and the hypertensive population was 4.6% and 8.8%, respectively. The logistic regression results shown that female sex [2.611 (1.591-4.583)], hypertension [2.638 (1.449-4.803)], systolic blood pressure (SBP) [1.021 (1.007-1.035)], serum uric acid (SUA) [1.004 (1.001-1.006)] and carotid intima-media thickness (CIMT) [67.670 (13.352-342.976)] were significantly associated with the risk of LVH (all P < 0.05). In the longitudinal analysis, fasting glucose [1.377 (1.087-1.754)], SBP [1.046 (1.013-1.080)] and female sex [1.242 (1.069-1.853)] were independent predictors for the occurrence of LVH in the fourth year of follow-up. CONCLUSIONS: Our study suggested that female sex, hypertension, SBP, SUA and CIMT were significantly associated with the risk of LVH in young people. In addition, fasting glucose, SBP and female sex are independent predictors of the occurrence of LVH in a young Chinese general population.
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Liao et al. (2021) conducted a cohort in Electrocardiographic left ventricular hypertrophy (n=1,515). Fasting glucose vs. Lower fasting glucose levels was evaluated on Occurrence of left ventricular hypertrophy (LVH) at 4 years (OR 1.377, 95% CI 1.087-1.754, p=0.008). In a young Chinese general population, higher fasting glucose (OR 1.377), systolic blood pressure, and female sex were independent predictors of incident left ventricular hypertrophy over a 4-year follow-up.
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