Key result
Astragalus mongholicus significantly reduced symptom duration (6.01 vs 9.28 days) and hospital stay, while improving cardiac function and Treg cell immunity in children with viral myocarditis compared to placebo.
Why the study?
Does Astragalus mongholicus oral liquid improve peripheral Treg cell immunity imbalance and cardiac function in children with viral myocarditis?
RCT (n=68)
Randomized
No
Does Astragalus mongholicus oral liquid improve peripheral Treg cell immunity imbalance and cardiac function in children with viral myocarditis?
Astragalus mongholicus treatment improves cardiac function and corrects Treg cell immunity imbalance in children with viral myocarditis.
Answers are grounded in this paper and cite their sources.
Supports adjunctive Astragalus use in pediatric viral myocarditis; extends RCT evidence for Treg immunomodulation in cardiac recovery.
Viral myocarditis (VMC) is a common cardiac disease, however, there still lacks an effective therapeutic strategy for VMC. Astragalus mongholicus (Fisch.) Bge (AB), a Chinese herb with some functional metabolites, may have some pharmacological effects on VMC. AB ingredients were measured by a full-scan LCQ mass spectrum. We aimed to explore the effects of AB on the VMC children by investigating peripheral Treg cell homeostasis. A total of 68 VMC children were random and evenly assigned into an AG group (received 10-mL AB oral liquid daily), and a CG group (received placebo daily). Peripheral blood mononuclear cells (PBMC) were obtained from peripheral blood and Treg cells were isolated. The levels of miR-146b, miR-155, Treg immunity activity and myocarditis biomarkers were measured in Treg cells. There were four main components (sucrose, calycosin, Astragaloside IV and calycosin-7-glucoside) in AB. The cases sinus tachycardia, frequent premature ventricular contractions, and supraventricular tachycardia were significantly reduced in the AG group (P < 0.05). Meanwhile, the myocardial enzymes and cardiac function indexes were improved in the AG group when compared with the CG group (P<0.05). The time of electrocardiogram recovery, symptom duration and hospital stay was shorter in the AG group than in the CG group (P<0.05). The levels of miR-146b and miR-155 were higher in the CG group than in the AG group (P<0.05). The levels of ROR-γt (retinoic acid receptor-related orphan nuclear receptor gamma), FoxP3 (forkhead transcription factor), IL-10 (interleukin-11) and TGF-β (transforming growth factor beta) were lower in the CG group than in the AG group (P<0.05). In contrast, the levels of IL-17, IL-21, CK-MB (creatine kinase-MB), cTnI (cardiac troponin I), GrB (granzyme B), sFasL (soluble fas ligand) and caspase-3 were higher in the CG group than in the AG group (P<0.05). Furthermore, the levels of ROR-γt, FoxP3, IL-10 and TGF-β were positively, whereas the levels of IL-17, IL-21, CK-MB, cTnI, GrB, sFasL and caspase-3 were negatively, associated with the levels of miR-146b and miR-155 (P<0.05). AB treatment improved cardiac functions, peripheral Treg cell immunity imbalance in the children with VMC by reducing the levels of miR-146b and miR-155.
No takes yet. Share an insight, caveat, or question.
Zhang et al. (2018) conducted an RCT in Viral Myocarditis (n=68). Astragalus mongholicus (Fisch.) Bge vs. Placebo was evaluated on Symptom duration (days) (p=0.01). Astragalus mongholicus significantly reduced symptom duration (6.01 vs 9.28 days) and hospital stay, while improving cardiac function and Treg cell immunity in children with viral myocarditis compared to placebo.
Synapse has enriched 10 related papers. Consider them for comparative context: