Key result
Heart-derived hormones coordinate cardiac function and target organ biology through various biochemical and signaling pathways, highlighting their clinical significance in the cardiovascular system.
Why the study?
Heart-derived hormones coordinate cardiac function and target organ biology through shared themes and unified mechanisms, motivating a review of their role in cardiac endocrinology.
The heart acts as an endocrine organ by secreting hormones like GDF-15, myostatin, and ANP/BNP that coordinate cardiac function with systemic target organ biology.
Supports endocrine perspective in CV assessment; leaves open targeted trials on GDF-15 and myostatin modulation.
The heart plays a central role in the circulatory system and provides essential oxygen, nutrients, and growth factors to the whole organism. The heart can synthesize and secrete endocrine signals to communicate with distant target organs. Studies of long-known and recently discovered heart-derived hormones highlight a shared theme and reveal a unified mechanism of heart-derived hormones in coordinating cardiac function and target organ biology. This paper reviews the biochemistry, signaling, function, regulation, and clinical significance of representative heart-derived hormones, with a focus on the cardiovascular system. This review also discusses important and exciting questions that will advance the field of cardiac endocrinology.
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Zhao et al. (2020) conducted a review in Cardiac endocrinology. Heart-derived hormones was evaluated. Heart-derived hormones coordinate cardiac function and target organ biology through various biochemical and signaling pathways, highlighting their clinical significance in the cardiovascular system.
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