Key result
This review explores the interactions between actin and myosin during cross-bridge cycling and discusses how muscle remodeling impacts the energetic demands of skeletal and cardiac muscle.
Key points are not available for this paper at this time.
Design
Review
Offers framework for remodeling energetics; leaves open clinical translation and prospective validation.
Numerous studies have explored the energetic properties of skeletal and cardiac muscle fibers. In this mini-review, we specifically explore the interactions between actin and myosin during cross-bridge cycling and provide a conceptual framework for the chemomechanical transduction that drives muscle fiber energetic demands. Because the myosin heavy chain (MHC) is the site of ATP hydrolysis and actin binding, we focus on the mechanical and energetic properties of different MHC isoforms. Based on the conceptual framework that is provided, we discuss possible sites where muscle remodeling may impact the energetic demands of contraction in skeletal and cardiac muscle.
No takes yet. Share an insight, caveat, or question.
Sieck et al. (2001) reported a review. This review explores the interactions between actin and myosin during cross-bridge cycling and discusses how muscle remodeling impacts the energetic demands of skeletal and cardiac muscle.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: