The study demonstrates significant sexual dimorphism in the neuroendocrine and immune responses to chronic stress in a rat model.
Urges caution against applying rat findings to patients; hypothesis-generating for sex-dimorphic neuroendocrine-immune effects in cardiovascular research.
mass of thymus and the content of Hassall's cells in it, and the increase of the sympathetic tone and corticosterone -on the other hand. Post-stress changes of the listed parameters in general were insignificant in females. Significant differences between intact and stressed females were reflected along the third root axis which contains the information on stress induced lowering levels of parathyrin and thyroxin, the intensity of Staph aureus phagocytosis by microphages and bactericidal capacity of blood macrophages, its content of eosinophils as well as the mass of the spleen. Instead, post-stress changes in the listed parameters were generally insignificant in males.
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Popovych et al. (2018) studied this question.
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