VEGF and thrombin induce DSCR-1 expression in endothelial cells, establishing a negative feedback loop that attenuates endothelial cell proliferation and angiogenesis.
Activation and dysfunction of the endothelium underlie many vascular disorders including atherosclerosis, tumor growth, and inflammation. Endothelial cell activation is mediated by many different extra-cellular signals, which result in overlapping yet distinct patterns of gene expression. Here we show, in DNA microarray analyses, that vascular endothelial growth factor (VEGF) and thrombin result in dramatic and rapid upregulation of Down syndrome critical region (DSCR)-1 gene encoding exons 4–7, a negative feedback regulator of calcium-calcineurin-NF-AT signaling. VEGF- and thrombin-mediated induction of the of and in the of in endothelial and in of vascular in and tumor growth in a in which VEGF- and thrombin-mediated induction of endothelial cell a negative feedback of gene induction and of signaling. a in the negative in Activation and dysfunction of the endothelium underlie many vascular disorders including atherosclerosis, tumor growth, and inflammation. Endothelial cell activation is mediated by many different extra-cellular signals, which result in overlapping yet distinct patterns of gene expression. Here we show, in DNA microarray analyses, that vascular endothelial growth factor (VEGF) and thrombin result in dramatic and rapid upregulation of Down syndrome critical region (DSCR)-1 gene encoding exons 4–7, a negative feedback regulator of calcium-calcineurin-NF-AT signaling. 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Minami et al. (Fri,) studied this question.