Key result
Coronary artery disease is associated with significantly reduced heart rate variability across all frequency domain parameters compared to normal reference values, including a marked reduction in total power (2171.70 vs 21222 ms2, p<0.001).
Why the study?
To carry out frequency domain analysis of heart rate variability in patients with coronary artery disease.
Are frequency domain parameters of heart rate variability decreased in patients with coronary artery disease compared to normal reference values?
Cross-Sectional (n=40)
No
Are frequency domain parameters of heart rate variability decreased in patients with coronary artery disease compared to normal reference values?
Heart rate variability is significantly decreased in patients with coronary artery disease, reflecting heightened sympathetic activation and potential risk for ventricular arrhythmias.
Supports CAD-HRV link suggesting autonomic imbalance; hypothesis-generating for risk stratification, should not yet change practice.
Objective: To carryout frequency domain analysis ofheart rate variability in patients with coronary arterydisease. Methods: Forty coronary artery disease patients with coronary artery stenosis greater than 70% of at least onevessel lumen were included. Patients with diabetes mellitus, atrial fibrillation, structural heart diseases andbundle branch block were excluded. DMS 300 4A Holter monitors were used to obtain long-term 12 leaddigital ECG recordings. Cardio Scan premium luxury software was used for analysis of heart rate variability. Results: The mean values of heart rate variability in patients were TP (2171.70 ± 1028.7), VLF (1661.41 ±807.88), LF (392.71 ± 227.92), HF (112.03 ± 77.90) and LF/HF ratio (4.03 ± 1.75). On comparison with normalreference values there was a significant decrease (p-value < 0.05) in all parameters except VLF (p-value =0.351). TP was reduced in all the patients (100%), VLF in 26 (65%), LF in 36 (90%), HF in 36 (90%) and LF/HFratio in 29 (72.5%) patients. The difference between the frequency of patients with decreased heart ratevariability was statistically significant (p-value < 0.05) except VLF (p-value = 0.082). Conclusion: Heart rate variability decreases significantly in patients with coronary artery disease.
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Mubarak et al. (2023) conducted a cross-sectional in Coronary artery disease (n=40). Coronary artery disease vs. Normal reference values was evaluated on Total Power (TP) of heart rate variability (ms2) (p=<0.001). Coronary artery disease is associated with significantly reduced heart rate variability across all frequency domain parameters compared to normal reference values, including a marked reduction in total power (2171.70 vs 21222 ms2, p<0.001).
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