Key result
Left ventricular isovolumic relaxation flow patterns were significantly associated with left ventricular filling patterns (p < 0.001), providing a potential index for evaluating diastolic function.
Why the study?
The study was designed to investigate the relationship between isovolumic relaxation flow patterns in the left ventricle and mitral inflow patterns.
Do isovolumic relaxation flow patterns assessed by vector flow mapping correlate with mitral inflow patterns in patients with coronary artery disease or dilated cardiomyopathy?
Cross-Sectional (n=146)
No
Do isovolumic relaxation flow patterns assessed by vector flow mapping correlate with mitral inflow patterns in patients with coronary artery disease or dilated cardiomyopathy?
Vector flow mapping demonstrates that isovolumic relaxation flow patterns are significantly associated with left ventricular diastolic filling patterns, offering a potential novel index for evaluating diastolic function.
Vector flow mapping of isovolumic relaxation may aid diastolic assessment in CAD/DCM; leaves open prospective validation before clinical adoption.
The purpose of this study was to investigate the relationship between isovolumic relaxation flow (IRF) patterns in left ventricle (LV) and mitral inflow patterns. Color Doppler loops were acquired for vector flow mapping in apical long-axis view in 57 patients with coronary artery disease, 31 patients with dilated cardiomyopathy, and 58 healthy controls. IRF patterns were classified into three categories: pattern A, apically directed flow; pattern B, bidirectional flow with small scattered vortices; and pattern C, a large vortex. All normals and patients with normal LV filling (n = 10) showed pattern A. Patients with impaired relaxation consisted of 31 (66%) patients having pattern A, 11 (23%) having pattern B, and 5 (11%) having pattern C. Patients with pseudonormal filling included 4 (31%) patients having pattern A, 7 (54%) having pattern B, and 2 (15%) having pattern C. In patients with restrictive filling, 14 (78%) showed pattern C, 4 (22%) showed pattern B, and no patient showed pattern A. IRF patterns were associated with LV filling patterns (χ 2 = 52.026, p < 0.001). There are significant relationships between LV filling and IRF patterns. IRF patterns may provide an index for evaluation of LV diastolic function.
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Yu et al. (2019) conducted a cross-sectional in Coronary artery disease and dilated cardiomyopathy (n=146). Left ventricular filling patterns vs. Normal left ventricular filling was evaluated on Association between isovolumic relaxation flow (IRF) patterns and left ventricular filling patterns (p=<0.001). Left ventricular isovolumic relaxation flow patterns were significantly associated with left ventricular filling patterns (p < 0.001), providing a potential index for evaluating diastolic function.
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