Key result
Compared to no preparation, oral antibiotic preparation alone significantly reduced the risk of surgical site infection after colorectal surgery (aOR 0.51, 95% CI 0.37-0.71).
Why the study?
Oral antibiotic preparation and mechanical bowel preparation reduce infection risk after colorectal surgery, but whether oral antibiotics can be used without mechanical preparation is unclear.
Does oral antibiotic preparation with or without mechanical bowel preparation reduce surgical site infection risk in patients undergoing colorectal surgery?
Meta-Analysis
Does oral antibiotic preparation with or without mechanical bowel preparation reduce surgical site infection risk in patients undergoing colorectal surgery?
Oral antibiotic preparation alone or combined with mechanical bowel preparation significantly reduces the risk of surgical site infection after colorectal surgery compared to no preparation.
Supports considering oral antibiotic preparation to reduce colorectal surgical site infection; leaves open confirmation via randomized trials.
To reduce the of risk infection after colorectal surgery, oral antibiotic preparation (OAP) and mechanical bowel preparation (MBP) can be applied. Whether OAP can be used without MBP is unclear. A meta-analysis of observational studies demonstrated comparable effectiveness of OAP with and without MBP regarding SSI risk.
No takes yet. Share an insight, caveat, or question.
Mulder et al. (2019) conducted a meta-analysis in Colorectal surgery. Oral antibiotic preparation (OAP) only vs. No preparation was evaluated on Surgical site infection (SSI) (aOR 0.51, 95% CI 0.37-0.71). Compared to no preparation, oral antibiotic preparation alone significantly reduced the risk of surgical site infection after colorectal surgery (aOR 0.51, 95% CI 0.37-0.71).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: