Population
Mouse and human models of cardiac development
Design
Review
Key result
The mouse and human heart are anatomically remarkably similar throughout development, with major differences seen only in the venous pole, warranting the use of mice as models for human heart disease.
Authors
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Supports mouse models for human cardiac development studies; leaves open functional validation in disease contexts.
Comparative anatomical analysis confirms that the mouse is a highly valid model for studying human cardiac development and congenital heart disease.
Wessels et al. (2003) conducted a review in Congenital heart disease and cardiac development. Mouse model vs. Human heart was evaluated. The mouse and human heart are anatomically remarkably similar throughout development, with major differences seen only in the venous pole, warranting the use of mice as models for human heart disease.