Numerous papers have been written on the fate of creatine in the organism, but no complete creatine balance has been obtained after oral or parenteral administration.The factors that must be investigated in order to trace administered creatine are (1) its excretion in the urine, (2) its partial conversion to creatinine, and (3) its deposition in the tissues; in addition, there is always a portion of this creatine which cannot be accounted for by any of our present methods.It is assumed by many workers that this "lost" creatine has undergone some anabolic change.Hunter (1) has discussed the factors which are responsible for the excretion of creatine and creatinine under various experimental conditions.The storage and the metabolism of administered creatine present a problem which is poorly understood.It was first demonstrated by Folin (2) that the body can metabolize small quantities of ingested creatine so that it could not be accounted for in any way.Benedict and Osterberg (3) and Rose, Ellis, and Helming (4) have shown that small quantities of creatine, fed daily, can be handled by dog and by man without any trace of creatine or extra creatinine appearing in the urine for an appreciable period of time.Chanutin (5) has shown that the creatine content of the tissues of the white rat is not appreciably affected by the prolonged administration of a 2.6 per cent'creatine diet.It has been found that in order to increase the creatine content of the tissues, it is necessary to increase the per cent of creatine in the diet (6).Obviously, creatine can be utilized or
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Chanutin et al. (1929) studied this question.