Experimental Renal Insufficiency the Effects of High Protein Diet in the Presence of Low Renal Function on the Kidneys, Aorta and Liver; Changes in the Blood Pressure and Concentration of Blood Metabolites

This investigation was undertaken to determine the effect of prolonged renal insufficiency on the blood pressure, and the influence of high or low protein diet on the course of chronic renal disease. The real cause of the progressive development of renal insufficiency in chronic nephritis is not clear. One view is that it is due to repeated infections. 1 Day 2 holds that it is due to a specific infection. Bell 3 believes that each new infection occurring in a nephritic patient causes closure of more glomerular capillaries and leaves the patient with a smaller kidney filter than before. Carter, Howe and Mason 4 suggest as a possibility that progressive damage to the kidneys may result from repeated minimal injury by means of irritating food substances, some of which are known and others as yet unrecognized. Injury to the remaining functioning tissue by high concentration of retained metabolites or by overactivity are other possible