Key result
Higher serum homocysteine correlates with lower ankle-brachial index in peripheral arterial disease.
Why the study?
Studies evaluating serum homocysteine as a biomarker of peripheral arterial disease severity based on ankle-brachial index in different populations were limited, and unstudied in Mataram.
Does serum homocysteine level correlate with Ankle-Brachial Index in asymptomatic outpatients with peripheral arterial disease?
Cross-Sectional (n=77)
No
Does serum homocysteine level correlate with Ankle-Brachial Index in asymptomatic outpatients with peripheral arterial disease?
Serum homocysteine level may serve as a biomarker for peripheral arterial disease severity as it correlates inversely with the ankle-brachial index.
Higher homocysteine was associated with lower ABI in PAD; hypothesis-generating for biomarker utility, needs prospective validation before practice change.
Patients with peripheral arterial disease have a higher risk of death compared to normal populations. There are several relatively new risk factors significantly increase the vulnerability to suffering from peripheral arterial disease, one of which is homocysteine. Studies investigating the role of serum homocysteine level as a biomarker of the severity of peripheral arterial disease based on an ankle-brachial index (ABI) in the different populations were still limited and it was never been studied in Mataram. This was a cross-sectional study aimed to investigate the correlation between serum homocysteine level and ABI in 77 peripheral artery disease (PAD) outpatients in Siti Hajar Hospital, Mataram. The diagnosis of PAD was based on ABI<0.9. Fasting serum homocysteine level was examined using the ELISA technique. Characteristic data collected were gender, age, hypertension, diabetes mellitus, and body mass index (BMI) category. There was a significant correlation between the increase of serum homocysteine levels and the decrease of ABI. The main risk factors for peripheral arterial disease in the subjects are hypertension, diabetes mellitus, and overweight/obesity. Serum homocysteine level is a predictor of peripheral arterial disease severity measured using ABI.
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Indrayana et al. (2020) conducted a cross-sectional in Peripheral Arterial Disease (PAD) (n=77). Serum homocysteine level was evaluated on Correlation between serum homocysteine level and Ankle-Brachial Index (ABI) (r = -0.323, p=0.004). Higher serum homocysteine levels significantly correlated with a decreased ankle-brachial index (r = -0.323, p=0.004) in patients with peripheral arterial disease.
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