Key result
Postoperative intravenous magnesium sulfate supplementation for 4 days significantly reduced the incidence of atrial fibrillation after isolated on-pump coronary artery bypass surgery from 35% to 18%.
Why the study?
Postoperative AF frequently complicates cardiac surgery, but the role of magnesium administration in preventing AF after isolated bypass surgery is not well established.
Does postoperative intravenous magnesium sulfate supplementation reduce the incidence of postoperative atrial fibrillation in patients undergoing isolated on-pump CABG?
RCT (n=200)
Placebo-controlled
Randomized
No
Does postoperative intravenous magnesium sulfate supplementation reduce the incidence of postoperative atrial fibrillation in patients undergoing isolated on-pump CABG?
Postoperative intravenous magnesium sulfate supplementation for 4 days significantly reduces the incidence of atrial fibrillation after isolated on-pump CABG.
Answers are grounded in this paper and cite their sources.
Supports 4-day postoperative IV magnesium to prevent POAF after on-pump CABG; confirms benefit in isolated CABG.
Objective: Atrial fibrillation (AF) is the most common arrhythmia complicating cardiac surgery and carries a high risk for significant morbidity and mortality in short and long term. Its prophylaxis remains crucial to improve outcomes. The role of magnesium administration in preventing the occurrence of AF after isolated bypass surgery is not well established. Variations of dose, timing and mode of administration have been proposed. The purpose of this study was to investigate the efficacy of 4-day postoperative intravenous magnesium supplementation on the incidence of postoperative AF.
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Dado et al. (2022) conducted an RCT in Postoperative atrial fibrillation after coronary artery bypass surgery (n=200). Intravenous magnesium sulfate vs. Placebo was evaluated on Incidence of postoperative atrial fibrillation (OR 0.41, 95% CI 0.11-0.64, p=0.006). Postoperative intravenous magnesium sulfate supplementation for 4 days significantly reduced the incidence of atrial fibrillation after isolated on-pump coronary artery bypass surgery from 35% to 18%.
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