Cyclophosphamide and lymphocyte subpopulations in Wegener's granulomatosis

In 10 patients with Wegener's granulomatosis, low doses of cyclophosphamide produced: severe lymphocytopenia of long duration even after therapy ceased; a greater percentage decrease in nonrosette forming lymphocytes than in rosette forming T‐lymphocytes; normal in vitro lymphocyte responses to mitogens (PHA, ConA, and PWM) with suppressed responses to one of two antigens tested (SK‐SD). This regimen did not cause severe granulocytopenia and was successful in inducing and maintaining long‐term clinical remissions.