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This review discusses the reductionist approach in cardiovascular research, detailing the progression from in-situ animal models to isolated hearts, papillary muscles, and single cardiomyocytes.
Discusses the reductionist approach and methodological evolution in studying myocardial performance and cardiac endothelium modulation.
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Urges integration beyond isolated cells; leaves open optimal strategies combining reductionist and in-situ models for endothelial research.
Stanislas U. Sys (1998) conducted a review in Cardiovascular system regulation and dysfunction. This review discusses the reductionist approach in cardiovascular research, detailing the progression from in-situ animal models to isolated hearts, papillary muscles, and single cardiomyocytes.
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