Key result
In sheep atrial myocytes, heart failure induced by rapid ventricular pacing resulted in an almost complete loss of t-tubules, increasing the distance of 50% of voxels from a membrane from 0.88 to 2.04 micrometers.
Absolute Event Rate: 2.04% vs 0.88%
Sheep atrial myocytes possess a substantial t-tubule network that synchronizes systolic Ca(2+) transients, which is markedly disrupted in heart failure.
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T-tubule disruption in ovine HF does not change practice; leaves open its role in human atrial Ca2+ handling.
Dibb et al. (2009) studied Heart failure. Heart failure induced by rapid ventricular pacing vs. Control cells was evaluated on Distance of 50% of voxels from a membrane (micrometers). In sheep atrial myocytes, heart failure induced by rapid ventricular pacing resulted in an almost complete loss of t-tubules, increasing the distance of 50% of voxels from a membrane from 0.88 to 2.04 micrometers.
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