Editorial - Mechanisms of Action of Natural Products Against Resistant Microorganisms

Antimicrobial resistance is a major public health threat driving the search for new therapeutic options. This special collection compiles studies on natural products active against resistant microorganisms. The results show that natural compounds rarely act on a single target, instead affecting metabolic pathways, cell wall integrity, and enhancing antibiotic and antifungal activity. Alkaloids disrupt energy metabolism and protein function, plant extracts act synergistically with antibiotics, and bee-derived products function as antimicrobial adjuvants. Overall, these findings highlight the translational potential of natural products in addressing antimicrobial resistance, supporting future antimicrobial drug development and innovation strategies in the fight against resistance globally.