Effectiveness of stem cells and platelet rich plasma in the treatment of oral submucous fibrosis

Introduction: Medical management of oral submucous fibrosis which is a common precancerous condition affecting population of Asian descent is still under investigations. Various modalities of medical management are detailed in the literature with varying degree of success. The major aim of the study is to evaluate the outcomes of platelet rich plasma and stem cells in the medical management of oral sub mucous fibrosis. Materials and Methods: Ten patients diagnosed with stage II, III and IV oral submucous fibrosis were included in the study. The stem cells and PRP derived from patients peripheral blood were injected intraorally into the areas of fibrosis. Mouth opening were recorded at the follow up visits. Results: All patients showed satisfactory results at the end of 6 months follow up interval. Mouth opening has improved post treatment; however we suggest a long term study with more number of patients. Conclusion: Stem cells and PRP can be a new effective modality for medical management of oral submucous fibrosis which requires detailed scientific studies.