Generalized Anxiety Disorder (GAD) is one of the most prevalent psychiatric disorders characterized by persistent and excessive anxiety affecting daily functioning and quality of life. Conventional management mainly includes pharmacotherapy and psychotherapy; however, long-term use of psychotropic drugs is associated with adverse effects, dependency, and reduced patient compliance. Homoeopathy, owing to its individualized and holistic approach, has been increasingly explored as an alternative therapeutic modality in anxiety disorders. The present review-based article aims to analyse existing literature regarding homoeopathic management of anxiety disorders and to establish the scientific basis for conducting a comparative study between centesimal and fifty millesimal potencies in GAD. Literature from randomized controlled trials, observational studies, systematic reviews, and epidemiological surveys demonstrates growing interest in homoeopathic interventions for anxiety-related disorders. Evidence suggests beneficial outcomes in symptom reduction, improved sleep, reduced psychotropic drug use, and better patient acceptability. However, comparative evidence regarding different potency scales remains scarce. Since centesimal and fifty millesimal potencies differ fundamentally in preparation, administration, and dynamic action, evaluating their comparative effectiveness in GAD becomes clinically relevant. This review highlights the need for further controlled studies to determine the therapeutic superiority, safety, and long-term effectiveness of these potency scales in managing generalized anxiety disorder.
Kumbhar et al. (Thu,) studied this question.