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June 5, 2026JCEM Case ReportsOpen Access

Tirzepatide for weight and behavior management in a patient with Smith-Magenis syndrome

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Authors

XLX Charlene LiaoTHTao HuangDHDavid S Hong

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Overview

Case report reveals tirzepatide improves weight and behavior in a patient with Smith-Magenis syndrome, suggesting new treatment avenues.

Key Points

  • To explore the effects of tirzepatide on weight and behavior in a patient with Smith-Magenis syndrome.
  • Case report of a 31-year-old woman with Smith-Magenis syndrome (17p11.2 deletion)
  • Treated with tirzepatide, titrated to 5 mg weekly
  • Follow-up included assessments of weight, glucose levels, and behavioral changes
  • Achieved 9.4% weight loss (7.3 kg) over 10 months
  • Improved fasting glucose levels
  • Notable reduction in aggression and food-seeking behavior reported by caregivers

Cite This Study

Liao et al. (2026) studied this question.

synapsesocial.com/papers/6a22696f763171746d547eefhttps://doi.org/10.1210/jcemcr/luag152
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