Association Between Vitamin D3 Level and Kidney Graft Function for One-Year Graft Outcomes in Patients with Kidney Transplantation

: Background Kidney transplantation is the best treatment option for patients with kidney failure. Despite the increased prevalence of transplantation, allograft rejection continues to cause morbidity and mortality among transplant recipients. Vitamin_D3 {25(OH)D} and renal function are still debated for long-term in renal transplant recipients. Aims Evaluation of 25(OH)D level in pre- and post-kidney transplantation as a strong evidence of successful kidney transplantation after one year and its association with kidney function pre- and post-kidney transplantation. Methods This study followed 85 patients (70 males and 15 females) aged 18–56 years pre- and post-kidney transplantation. 25(OH)D, blood urea nitrogen (BUN), creatinine clearance (CrCl), creatinine, and BUN/creatinine ratio were tested pre- and post-kidney transplant. The correlation between 25(OH)D with BUN, creatinine, CrCl, and BUN/creatinine ratio was analyzed. Multiple regression analysis controlled for confounders. A ROC curve analysis study of 25(OH)D assessed as a successful marker in kidney transplant recipients. Results Post-transplant serum 25(OH)D level exhibited significantly higher compared with pre-transplant (P < 0.001). 25(OH)D strong positively correlated with BUN/creatinine ratio (r=0.64, P < 0.001), CrCl (r= 0.692, P < 0.001) and strong negatively correlated with BUN (r= -0.69, P < 0.001), creatinine (r= -0.761, P < 0.001). Multiple regression analysis showed that CrCl and BUN/creatinine ratio were independently associated with 25(OH)D (p <0.001). The area under the ROC curve analysis for 25(OH)D was 0.954 (95% CI: 0.894-1). Conclusion Vitamin_D3 levels are strongly associated with kidney function, particularly graft function. Furthermore, the 25(OH)D level can be used as a good indicator of successful graft function.