Pharmacodynamic interaction of ethyl acetate fraction from alcoholic extract of Phyllanthus niruri leaves with gentamicin-induced nephrotoxicity in Wister albino rats

Objectives: The current study was plotted for evaluating nephroprotective effects of the ethyl acetate fraction from the alcoholic extract of phyllanthus niruri leaves on gentamicin-induced nephrotoxicity in rats’ models. Materials and Methods: Overall 24 albino rats were randomised into 4 groups with 6 rats in each group. The first group served as a control with normal saline 10 mL/kg and negative control group received gentamicin 80 mg/kg i.p. injection. The third group was administered the ethyl acetate fraction of P. niruri (EAFPN) 200 mg/kg orally. EAFPN 400 mg/kg orally was given to the fourth group. After 9 th day, animal was sacrificed for histopathological and haematological estimation. Results: Histopathological reports revealed nephroprotective results with EAFPN leaves. Blood urea nitrogen, serum urea and serum creatinine exhibited significant improvement when compared with control group. Conclusion: These findings suggest that the EAFPN may be promising in protecting nephrotoxicity induced by gentamicin.