Epidemiology and Outcomes Among Adults With Severe Community-Acquired Bacterial Pneumonia Hospitalized in the United States, 2021–2024

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Key Points

To analyze the population, treatment approaches, and outcomes for severe community-acquired bacterial pneumonia (sCABP) in hospitalized adults in the U.S.
Retrospective quasi-cohort study design
Analysis of data from 849 U.S. acute care hospitals (2021-2024)
Comparison of patients defined by ICU-sCABP and ATS-sCABP criteria
51.2% of patients met ICU-sCABP definition; 78.0% met ATS-sCABP definition.
Hospital mortality rates were similar: 15.6% for ICU-sCABP and 15.0% for ATS-sCABP.
Mechanical ventilation practices changed since the pandemic, with a reduction in invasive mechanical ventilation (IMV) usage.

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Retrospective quasi-cohort study examines treatment and outcomes of severe pneumonia in adults, highlighting high mortality rates.

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Zilberberg et al. (2026) studied this question.

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