ABSTRACT Glaucosciadium cordifolium (Apiaceae) is an Anatolian aromatic traditionally used as a remedy. This study compared extraction yields, chemical profiles, bioactivities, and in‐silico pharmacology across organs and solvents. Aqueous extraction was most efficient for flowering aerial parts and roots, whereas methanol favored fruits. Hydrodistillation yielded 0.2% essential oil rich in α‐pinene (27.3%) and limonene (27.6%); GC–MS identified 51 constituents. FTIR confirmed phenolic, carbohydrate, and lipid functionalities in the extracts. Biologically, the essential oil showed the strongest α‐amylase inhibition, while root extracts showed weak to moderate cholinesterase inhibition. Methanolic fruit and root extracts exhibited the highest ABTS• + scavenging. Docking analysis suggested potential interactions of germacrene D, β‐caryophyllene, and carvacrol as key ligands interacting with catalytic residues. ADME/Tox predictions indicated carvacrol and terpinen‐4‐ol as more orally bioavailable and safer, whereas germacrene D and β‐caryophyllene showed lower solubility and higher risk. Overall, G. cordifolium displays moderate antidiabetic, anticholinesterase, and antioxidant potential.
Aydın et al. (Mon,) studied this question.