Outcomes of Self-Administered Outpatient Parenteral Antibiotic Therapy in Patients with Osteomyelitis of the Foot

Arthur Tarricone; Allen Gee; Nitish Thirugnanasambandam; Dane K. Wukich; Prakash Krishnan; Lawrence A. Lavery

doi:10.1177/15347346261458188

June 3, 2026The International Journal of Lower Extremity Wounds

Outcomes of Self-Administered Outpatient Parenteral Antibiotic Therapy in Patients with Osteomyelitis of the Foot

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Key Points

This research aims to compare the outcomes of self-administered outpatient parenteral antibiotic therapy (S-OPAT) with healthcare administered outpatient parenteral antimicrobial therapy (H-OPAT) in osteomyelitis patients.
Retrospective cohort study of 202 subjects with foot osteomyelitis admitted for treatment and followed for 1 year.
134 subjects received H-OPAT, and 68 received S-OPAT.
Primary outcomes included reinfection, wound healing, rehospitalization, and length of stay.
S-OPAT patients had a higher likelihood of rehospitalization with an odds ratio (O.R) of 2.10 [1.11, 3.70].
S-OPAT patients were less likely to achieve complete wound healing within 90 days (O.R = 0.49 [0.25, 0.96]).
Kaplan-Meier analysis indicated longer healing times for S-OPAT patients (183.7 ± 118.9 days) compared to H-OPAT (136.0 ± 105.2 days, p = 0.01).

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Implication

Retrospective cohort study compares outcomes of self-administered versus healthcare-administered antibiotics in foot osteomyelitis, indicating significant rehospitalization risks.

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Tarricone et al. (2026) studied this question.

synapsesocial.com/papers/6a2269c9763171746d548626 https://doi.org/10.1177/15347346261458188

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Outcomes of Self-Administered Outpatient Parenteral Antibiotic Therapy in Patients with Osteomyelitis of the Foot

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Outcomes of Self-Administered Outpatient Parenteral Antibiotic Therapy in Patients with Osteomyelitis of the Foot

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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