A low power high efficiency neural signal recording amplifier with a novel multi-chopper technique is proposed and implemented in 180nm CMOS. The input referred rms noise is 1.54µV (1–500Hz) with 266nA tail current. The result corresponds to a 1.38 noise efficiency factor, which is the best reported among current state-of-the-art amplifiers.
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Chen et al. (2014) studied this question.