Why the study?
Long noncoding RNAs participate in many biological processes, but their expression profiles and potential functions in neonatal hypoxic-ischemic encephalopathy remained to be investigated.
What are the differential expression profiles of lncRNAs and mRNAs in the peripheral blood of neonates with HIE compared to controls?
What are the differential expression profiles of lncRNAs and mRNAs in the peripheral blood of neonates with HIE compared to controls?
This study identifies distinct lncRNA and mRNA expression profiles in neonates with HIE, providing potential new biomarkers or therapeutic targets.
Long noncoding RNAs (lncRNAs) have been shown to participate in many biological processes. To investigate the expression profiles of lncRNAs and their potential functions in neonatal hypoxic-ischemic encephalopathy (HIE), we detected the lncRNA and messenger RNA (mRNA) expression in the peripheral blood samples from HIE patients and controls using a microarray. A total of 376 lncRNAs and 126 mRNAs were differentially expressed between the HIE and the non-HIE samples (fold change > 2). Quantitative real-time polymerase chain reaction was used to validate the microarray data. Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes pathway analysis were performed to determine the gene function. Furthermore, the lncRNA-mRNA coexpression network was generated to predict the potential targets of lncRNAs. In conclusion, our study first demonstrated the differential expression profiles of lncRNAs in the whole blood of infants with HIE and may provide a new view of the distinct lncRNA functions in HIE.
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Dong et al. (2018) studied this question.
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