Key result
Nonatherosclerotic cardiac diseases, including cardiomyopathies, inflammatory myocardial diseases, and ion channel disorders, are important causes of sudden cardiac death.
This review highlights nonatherosclerotic causes of sudden cardiac death, including cardiomyopathies, inflammatory myocardial diseases, and ion channel disorders, as well as genetic and toxic etiologies.
Nonatherosclerotic causes merit inclusion in sudden cardiac death evaluation; leaves open prospective validation of genetic screening.
Sudden cardiac death (SCD) accounts for approximately 300,000 cardiac events in the United States each year, representing an overall incidence of 0.1-0.2% per year. Although the vast majority of these may be attributed to coronary atherosclerosis, a wide variety of nonatherosclerotic-related cardiac diseases have been associated with SCD. This review highlights three general categories of cardiac disease not related to atherosclerosis: the cardiomyopathies, inflammatory myocardial diseases, and ion channel disorders. The important role played by genetics in some of these cardiovascular diseases is presented as well as toxic and drug-related etiologies.
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Ladich et al. (2006) conducted a review in Sudden cardiac death not related to coronary atherosclerosis. Nonatherosclerotic cardiac diseases (cardiomyopathies, inflammatory myocardial diseases, ion channel disorders) was evaluated on Sudden cardiac death. Nonatherosclerotic cardiac diseases, including cardiomyopathies, inflammatory myocardial diseases, and ion channel disorders, are important causes of sudden cardiac death.
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