The history of the Indian populations from the Valley of Tlaxcala since the Spanish conquest of Mexico has been one of fission and transplantation. A number of Tlaxcaltecan families were relocated by the Spanish and founded new communities such as Saltillo and Cuanalan outside the Valley of Tlaxcala. The contemporary genetic structure of these people reflects their ethnohistory. Genetic distances between Tlaxcaltecan groups are the result of differential systematic pressure acting upon them.
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Crawford et al. (1980) studied this question.
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