Key result
Inferior vena cava ligation between the renal veins in rats induced renal congestion, which significantly reduced renal blood flow and glomerular filtration rate, and caused pericyte detachment and tubulointerstitial injury.
Population
Male Sprague-Dawley rats (7- to 9-weeks old, 250–350 g)
Comparison
Inferior vena cava ligation between the renal… vs Non-congestive right kidneys and sham-operated…
Design
Preclinical
Follow-up
Up to 3 days (acute and subacute phases)
Authors
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Renal congestion may drive kidney injury; this rat model extends preclinical evidence but leaves open clinical translation.
p-value: p=<0.05
This novel rat model demonstrates that renal congestion increases renal interstitial hydrostatic pressure and induces pericyte detachment, leading to tubulointerstitial injury and extracellular matrix expansion.
Shimada et al. (2018) studied Renal congestion. Inferior vena cava (IVC) ligation between renal veins vs. Sham operation or contralateral non-congestive right kidney was evaluated on Renal hemodynamics (renal blood flow, glomerular filtration rate, and renal interstitial hydrostatic pressure) and tubulointerstitial injury (p=<0.05). Inferior vena cava ligation between the renal veins in rats induced renal congestion, which significantly reduced renal blood flow and glomerular filtration rate, and caused pericyte detachment and tubulointerstitial injury.
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