Why the study?
Does dalteparin protect against the thrombogenic effects of 5-fluorouracil on the vascular endothelium in a rabbit model?
Population
Rabbit model
Comparison
5-fluorouracil, dalteparin, and the combination… vs Control group
Design
Preclinical
Follow-up
30 days
Authors
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May warrant caution with dalteparin during 5-FU therapy; leaves open net endothelial effects in patients.
Does dalteparin protect against the thrombogenic effects of 5-fluorouracil on the vascular endothelium in a rabbit model?
Dalteparin may protect against 5-FU-induced thrombogenic effects on the vascular endothelium, but it may also independently impair endothelial healing.
Kinhult et al. (2001) studied this question.
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