Key result
Intravenous sedation during impacted mandibular third molar extraction significantly lowered the low-frequency/high-frequency ratio and decreased post-treatment anxiety scores (P<0.01).
Why the study?
Intravenous sedation is thought to reduce anxiety and fluctuations in autonomic nerve activity during dental procedures, but its specific effects during impacted mandibular third molar extraction required investigation.
Does intravenous sedation reduce sympathetic nervous system activity and anxiety in healthy women undergoing impacted mandibular third molar extraction?
Observational (n=34)
Does intravenous sedation reduce sympathetic nervous system activity and anxiety in healthy women undergoing impacted mandibular third molar extraction?
Intravenous sedation during impacted mandibular third molar extraction suppresses sympathetic nervous system activity and decreases post-extraction anxiety in healthy women.
Answers are grounded in this paper and cite their sources.
May support IV sedation to reduce anxiety during third molar extraction; hypothesis-generating and requires randomized confirmation.
Purpose Intravenous sedation is considered to decrease patient anxiety and tension during dental treatment, thereby reducing fluctuations in autonomic nerve activity and the risk of medical emergencies. We hypothesized that intravenous sedation would suppress the sympathetic nervous system during tooth extraction and relieve patient anxiety. Accordingly, the purpose of this study was to investigate the effects of intravenous sedation on autonomic nerve activity and psychological state during impacted mandibular third molar (IMTM) extraction. Methods This prospective study included 40 healthy women scheduled for IMTM extraction under local anesthesia alone (control group; n = 20) or local anesthesia and intravenous sedation (sedation group; n = 20); of these, 34 women were evaluated. Heart rate variability (HRV) was analyzed to evaluate autonomic nerve activity. HRV and circulatory dynamics were measured during the treatment. The Modified Dental Anxiety scale and State‐Trait Anxiety Inventory (STAI‐S and STAI‐T) scores were obtained before treatment. STAI‐S scores were also obtained after treatment. Descriptive and bivariate statistical analyses were conducted, and a P ‐value <.05 was considered statistically significant. Results The low‐frequency/high‐frequency ratio was lower in the sedation group than in the control group ( P < .01). Compared with the control group, the sedation group showed a significantly greater decrease in post‐treatment STAI‐S scores relative to pre‐treatment scores ( P < .01). Conclusions The findings suggest that sedation suppresses the sympathetic nervous system during IMTM extraction and decreases anxiety after the extraction. Further research should elucidate the mechanisms by which sedation suppresses the sympathetic nervous system.
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Uchino et al. (2020) conducted an observational in Impacted mandibular third molar extraction (n=34). Intravenous sedation vs. Local anesthesia alone was evaluated on Autonomic nerve activity (low-frequency/high-frequency ratio) and psychological state (STAI-S scores) (p=<0.01). Intravenous sedation during impacted mandibular third molar extraction significantly lowered the low-frequency/high-frequency ratio and decreased post-treatment anxiety scores (P<0.01).
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