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The radiation sensitivity of a line of transplanted murine lymphoma cells determined by means of the spleen colony assay is characterized by Do of 114 rads (1). This value is significantly lower than the value of 160 rads obtained for other lines of lymphoma cells by means of a serial dilution, end-point assay as reported by Hewitt and Wilson (2) and confirmed by Berry and Andrews (3). In order to clarify whether this disagreement is a result of an inherent difference in the sensitivity of the cell lines used, differences in the irradiation conditions employed, or some difference in the criteria of viability used by the two assays, we have measured the survival of one cell line by means of the two assay procedures. We have found that a single line of lymphoma cells, irradiated under well-defined conditions, can yield two distinctly different survival curves when determed by the two assay methods.
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Bush et al. (1965) studied this question.
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