Key result
Cardiac-selective GLUT4 deficiency in fasted mice resulted in depressed glucose utilization, profound systolic and diastolic dysfunction, and accelerated ATP depletion during ischemia.
Why the study?
What is the role of GLUT4 in mediating increased glycolytic flux and protecting against ischemic injury in the heart?
What is the role of GLUT4 in mediating increased glycolytic flux and protecting against ischemic injury in the heart?
GLUT4 is an important mediator of enhanced glycolysis during ischemia, providing a critical protective mechanism against ischemic injury.
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GLUT4 may protect against ischemic injury; leaves open therapeutic targeting pending human studies.
Tian et al. (2001) studied Myocardial ischemia. Cardiac-selective GLUT4 deficiency vs. Normal GLUT4 function / Fed state vs 20-hour fast was evaluated on Glucose utilization, systolic and diastolic dysfunction, and ATP depletion during ischemia. Cardiac-selective GLUT4 deficiency in fasted mice resulted in depressed glucose utilization, profound systolic and diastolic dysfunction, and accelerated ATP depletion during ischemia.
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