Psychologic measures of mood, distress and psychologic vulnerability were obtained from young male volunteers participating in experimental tularemia studies before exposure, during incubation of disease and during the acute and convalescent illness periods. Daily temperature and fever records were maintained. It was found that the onset of negative mood feelings was prodromal to fever in the majority of subjects. Psychologically vulnerable subjects tended to react to a greater degree and to show more severe illness as measured by the duration of fever than did the nonvulnerable subjects.
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Arthur Canter (1972) studied this question.