Key result
Increasing inspired oxygen fraction from 0.21 to 1.0 in awake patients significantly reduced mean cardiac index (3.38 to 3.03 L/min/m2; P<0.001), with similar effects during anaesthesia.
Why the study?
Does changing inspired oxygen fraction (FiO2) alter haemodynamic parameters in awake and anaesthetized patients?
Population
30 ASA I-II patients (15 in propofol group, 15 in sevoflurane group)
Comparison
Changing inspired oxygen fraction between 0.3… vs Baseline FiO2 (0.21 or 1.0 depending on the phase)
Design
Cohort
Authors
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High FiO2 may reduce cardiac index perioperatively; hypothesis-generating and should not yet alter practice.
Does changing inspired oxygen fraction (FiO2) alter haemodynamic parameters in awake and anaesthetized patients?
Absolute Event Rate: 3.03% vs 3.38%
p-value: p=<0.001
Changing inspired oxygen fraction has significant haemodynamic effects, including changes in cardiac index and heart rate, in both awake and anaesthetized patients.
Anderson et al. (2005) studied Patients undergoing anaesthesia (n=30). Increased inspired oxygen fraction (FiO2) vs. Baseline FiO2 (0.21 or 0.3) was evaluated on Mean cardiac index (L min(-1) m(-2)) in awake patients (p=<0.001). Increasing inspired oxygen fraction from 0.21 to 1.0 in awake patients significantly reduced mean cardiac index (3.38 to 3.03 L/min/m2; P<0.001), with similar effects during anaesthesia.
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